Selank & Semax

Selank and Semax are neuro-peptides from the Moscow Institute of Molecular Genetics. Selank is anxiolytic without causing drowsiness; Semax is a nootropic. Both are approved as medicines in Russia (evidence level 3).

How do Selank and Semax work?

Selank is a fragment of the body's own tuftsin and gently modulates dopamine and serotonin via enkephalin breakdown. Semax is based on ACTH and mainly raises BDNF - a "fertiliser" for the brain that promotes neuroplasticity (new synapses). Both peptides act on the nervous system rather than on metabolism, which sets them apart from the GLP-1 weight-loss drugs in the Peptipedia library.

What are they used for?

Selank as an anxiolytic: it relieves anxiety and tension without sedating, clouding cognition or causing physical dependence. Semax as "brain doping": more concentration, learning capacity and focus. Both are usually given as a nasal spray. People interested in cognition often also explore mitochondrial energy peptides such as MOTS-c. Want to keep notes on what you try? Create a free account.

What does the evidence say?

In Russia they have been approved after clinical studies for decades; Semax is even used there for acute stroke. Western regulators (FDA/EMA) mostly do not recognise these studies, but also do not require their own approvals - commercial interest in Russian patents is low. For reconstitution and dosing maths, see the dosage calculator and the FAQ.

Note: Educational information, not medical advice. Many of these substances are experimental and not approved for human use.